![\"C\u00e1c](\"https:\/\/psychiatryfoundation.com\/\/vi\/wp-content\/uploads\/shared\/skin-2404163_1280.jpg\")
“`html<\/p>\n“`html<\/p>\n
C\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh nh\u01b0 Alzheimer, Parkinson v\u00e0 x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (ALS) \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng tri\u1ec7u ng\u01b0\u1eddi tr\u00ean th\u1ebf gi\u1edbi. S\u1ef1 ti\u1ebfn tri\u1ec3n ch\u1eadm c\u1ee7a ch\u00fang v\u00e0 thi\u1ebfu c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7t \u0111\u1ec3 hi\u1ec7u qu\u1ea3 khi\u1ebfn ch\u00fang tr\u1edf th\u00e0nh m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn \u0111\u1ed1i v\u1edbi y t\u1ebf c\u00f4ng c\u1ed9ng. Nh\u1eefng b\u1ec7nh l\u00fd n\u00e0y chia s\u1ebb c\u00e1c c\u01a1 ch\u1ebf chung, bao g\u1ed3m r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ty th\u1ec3, s\u1ef1 t\u00edch t\u1ee5 b\u1ea5t th\u01b0\u1eddng c\u1ee7a protein, r\u1ed1i lo\u1ea1n b\u1ed9 x\u01b0\u01a1ng t\u1ebf b\u00e0o, suy y\u1ebfu synap v\u00e0 vi\u00eam m\u1ea1n t\u00ednh c\u1ee7a h\u1ec7 th\u1ea7n kinh.<\/p>\n
Trong b\u1ec7nh Alzheimer, s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a peptide beta-amyloid h\u00ecnh th\u00e0nh c\u00e1c m\u1ea3ng b\u00e1m, g\u00e2y r\u1ed1i lo\u1ea1n giao ti\u1ebfp gi\u1eefa c\u00e1c n\u01a1-ron. Nh\u1eefng \u0111\u00e1m n\u00e0y k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a n\u00e3o, vi th\u1ec3 v\u00e0 t\u1ebf b\u00e0o h\u00ecnh sao, g\u00e2y ra t\u00ecnh tr\u1ea1ng vi\u00eam k\u00e9o d\u00e0i. Ph\u1ea3n \u1ee9ng n\u00e0y l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam s\u1ef1 suy tho\u00e1i c\u1ee7a synap v\u00e0 th\u00fac \u0111\u1ea9y s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c m\u1ea3nh v\u1ee1 protein tau, m\u1ed9t \u0111\u1eb7c \u0111i\u1ec3m kh\u00e1c c\u1ee7a b\u1ec7nh. C\u00f9ng nhau, nh\u1eefng qu\u00e1 tr\u00ecnh n\u00e0y d\u1eabn \u0111\u1ebfn m\u1ea5t tr\u00ed nh\u1edb v\u00e0 kh\u1ea3 n\u0103ng nh\u1eadn th\u1ee9c d\u1ea7n d\u1ea7n, khi\u1ebfn c\u00e1c nhi\u1ec7m v\u1ee5 h\u00e0ng ng\u00e0y tr\u1edf n\u00ean kh\u00f3 kh\u0103n h\u01a1n.<\/p>\n
B\u1ec7nh Parkinson bi\u1ec3u hi\u1ec7n b\u1eb1ng run r\u1ea9y, ch\u1eadm ch\u1ea1p trong v\u1eadn \u0111\u1ed9ng v\u00e0 r\u1ed1i lo\u1ea1n th\u0103ng b\u1eb1ng. N\u00f3 \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi s\u1ef1 tho\u00e1i h\u00f3a c\u1ee7a c\u00e1c n\u01a1-ron s\u1ea3n xu\u1ea5t dopamine trong m\u1ed9t v\u00f9ng n\u00e3o g\u1ecdi l\u00e0 ch\u1ea5t \u0111en. S\u1ef1 t\u1eadp h\u1ee3p c\u1ee7a protein alpha-synuclein h\u00ecnh th\u00e0nh th\u1ec3 Lewy, ch\u1eb7n s\u1ef1 s\u1ea3n xu\u1ea5t dopamine v\u00e0 l\u00e0m gi\u00e1n \u0111o\u1ea1n vi\u1ec7c truy\u1ec1n t\u1ea3i t\u00edn hi\u1ec7u th\u1ea7n kinh. C\u00e1c \u0111\u1ed9t bi\u1ebfn gen, ch\u1eb3ng h\u1ea1n nh\u01b0 nh\u1eefng \u0111\u1ed9t bi\u1ebfn \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn gen PINK1 ho\u1eb7c Parkin, c\u0169ng ng\u0103n c\u1ea3n vi\u1ec7c lo\u1ea1i b\u1ecf c\u00e1c ty th\u1ec3 b\u1ecb l\u1ed7i, t\u1eeb \u0111\u00f3 l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam c\u0103ng th\u1eb3ng oxy h\u00f3a v\u00e0 ch\u1ebft t\u1ebf b\u00e0o.<\/p>\n
B\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (ALS) t\u1ea5n c\u00f4ng c\u00e1c n\u01a1-ron v\u1eadn \u0111\u1ed9ng, g\u00e2y ra s\u1ef1 y\u1ebfu c\u01a1 ti\u1ebfn tri\u1ec3n v\u00e0 li\u1ec7t. S\u1ef1 t\u00edch t\u1ee5 c\u1ee7a c\u00e1c protein \u0111\u1ed9c h\u1ea1i, ch\u1eb3ng h\u1ea1n nh\u01b0 SOD1 ho\u1eb7c TDP-43, l\u00e0m r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u1ee7a ty th\u1ec3 v\u00e0 t\u0103ng c\u0103ng th\u1eb3ng oxy h\u00f3a. Ngo\u00e0i ra, s\u1ef1 d\u01b0 th\u1eeba glutamate, m\u1ed9t ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh, k\u00edch th\u00edch qu\u00e1 m\u1ee9c c\u00e1c th\u1ee5 th\u1ec3 NMDA v\u00e0 AMPA, d\u1eabn \u0111\u1ebfn s\u1ef1 x\u00e2m nh\u1eadp \u1ed3 \u1ea1t c\u1ee7a canxi v\u00e0o c\u00e1c t\u1ebf b\u00e0o. S\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng kho\u00e1ng ch\u1ea5t n\u00e0y l\u00e0m h\u1ecfng ty th\u1ec3 v\u00e0 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh tho\u00e1i h\u00f3a n\u01a1-ron.<\/p>\n
C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7n t\u1ea1i ch\u1ee7 y\u1ebfu nh\u1eb1m m\u1ee5c \u0111\u00edch l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng. \u0110\u1ed1i v\u1edbi b\u1ec7nh Alzheimer, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf acetylcholinesterase, ch\u1eb3ng h\u1ea1n nh\u01b0 galantamine, duy tr\u00ec m\u1ee9c acetylcholin, m\u1ed9t ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh thi\u1ebft y\u1ebfu cho tr\u00ed nh\u1edb. C\u00e1c ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 NMDA, ch\u1eb3ng h\u1ea1n nh\u01b0 memantine, h\u1ea1n ch\u1ebf s\u1ef1 d\u01b0 th\u1eeba canxi trong c\u00e1c n\u01a1-ron, t\u1eeb \u0111\u00f3 gi\u1ea3m \u0111\u1ed9c t\u00ednh. Trong b\u1ec7nh Parkinson, L-DOPA b\u00f9 \u0111\u1eafp s\u1ef1 thi\u1ebfu h\u1ee5t dopamine, trong khi c\u00e1c ch\u1ea5t ch\u1ee7 v\u1eadn dopamine m\u00f4 ph\u1ecfng t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3. \u0110\u1ed1i v\u1edbi b\u1ec7nh ALS, riluzole gi\u1ea3m s\u1ef1 d\u01b0 th\u1eeba glutamate, b\u1ea3o v\u1ec7 m\u1ed9t ph\u1ea7n c\u00e1c n\u01a1-ron.<\/p>\n
C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ed5i m\u1edbi m\u1edf ra nh\u1eefng tri\u1ec3n v\u1ecdng m\u1edbi. Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch s\u1eed d\u1ee5ng c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u1ec3 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o c\u00e1c \u0111\u00e1m protein \u0111\u1ed9c h\u1ea1i. C\u00e1c kh\u00e1ng th\u1ec3 nh\u01b0 lecanemab ho\u1eb7c aducanumab g\u1eafn v\u00e0o c\u00e1c m\u1ea3ng b\u00e1m beta-amyloid, gi\u00fap lo\u1ea1i b\u1ecf ch\u00fang nh\u1edd c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch. \u0110\u1ed1i v\u1edbi b\u1ec7nh Parkinson, c\u00e1c kh\u00e1ng th\u1ec3 ch\u1ed1ng alpha-synuclein, ch\u1eb3ng h\u1ea1n nh\u01b0 prasinezumab, \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 trung h\u00f2a c\u00e1c t\u1eadp h\u1ee3p g\u00e2y tho\u00e1i h\u00f3a.<\/p>\n
Li\u1ec7u ph\u00e1p gen \u0111\u1ec1 xu\u1ea5t s\u1eeda ch\u1eefa c\u00e1c b\u1ea5t th\u01b0\u1eddng di truy\u1ec1n g\u00e2y ra c\u00e1c b\u1ec7nh n\u00e0y. C\u00e1c vector virus \u0111\u01b0a c\u00e1c gen \u0111i\u1ec1u tr\u1ecb v\u00e0o n\u00e3o \u0111\u1ec3 h\u1ed7 tr\u1ee3 s\u1ef1 s\u1ed1ng s\u00f3t c\u1ee7a c\u00e1c n\u01a1-ron, gi\u1ea3m s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a c\u00e1c protein \u0111\u1ed9c h\u1ea1i ho\u1eb7c \u0111i\u1ec1u ch\u1ec9nh vi\u00eam. V\u00ed d\u1ee5, c\u00e1c gen nh\u01b0 NGF ho\u1eb7c BDNF th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 b\u1ea3o v\u1ec7 c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh. \u0110\u1ed1i v\u1edbi b\u1ec7nh ALS, c\u00e1c k\u1ef9 thu\u1eadt im l\u1eb7ng gen nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o c\u00e1c gen \u0111\u1ed9t bi\u1ebfn SOD1 ho\u1eb7c C9ORF72, t\u1eeb \u0111\u00f3 gi\u1ea3m s\u1ea3n xu\u1ea5t c\u00e1c protein c\u00f3 h\u1ea1i.<\/p>\n
C\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean c\u0169ng mang l\u1ea1i nh\u1eefng gi\u1ea3i ph\u00e1p \u0111\u1ea7y h\u1ee9a h\u1eb9n. Galantamine, \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t t\u1eeb hoa tuy\u1ebft anh, \u1ee9c ch\u1ebf acetylcholinesterase v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh Alzheimer. Ngh\u1ec7 v\u00e0 silymarin, nh\u1edd t\u00ednh ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng oxy h\u00f3a, h\u1ea1n ch\u1ebf s\u1ef1 t\u1eadp h\u1ee3p c\u1ee7a protein v\u00e0 b\u1ea3o v\u1ec7 c\u00e1c n\u01a1-ron. Mucuna pruriens<\/em>, gi\u00e0u L-DOPA, l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh Parkinson \u0111\u1ed3ng th\u1eddi gi\u1ea3m c\u0103ng th\u1eb3ng oxy h\u00f3a. Niacin, hay vitamin B3, k\u00edch th\u00edch s\u1ea3n xu\u1ea5t dopamine v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng v\u1eadn \u0111\u1ed9ng trong nhi\u1ec1u b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh.<\/p>\n C\u00f4ng ngh\u1ec7 nano c\u00e1ch m\u1ea1ng h\u00f3a vi\u1ec7c v\u1eadn chuy\u1ec3n thu\u1ed1c. C\u00e1c h\u1ea1t nano, h\u1eefu c\u01a1 ho\u1eb7c v\u00f4 c\u01a1, xuy\u00ean qua h\u00e0ng r\u00e0o m\u00e1u-n\u00e3o, m\u1ed9t r\u00e0o c\u1ea3n l\u1edbn \u0111\u1ed1i v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng. C\u00e1c exosome, nh\u1eefng t\u00fai nh\u1ecf c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c, \u0111i\u1ec1u ch\u1ec9nh vi\u00eam v\u00e0 th\u00fac \u0111\u1ea9y s\u1ef1 t\u00e1i sinh n\u01a1-ron. C\u00e1c h\u1ea1t nano lipid b\u1ea3o v\u1ec7 thu\u1ed1c v\u00e0 v\u1eadn chuy\u1ec3n tr\u1ef1c ti\u1ebfp \u0111\u1ebfn c\u00e1c v\u00f9ng b\u1ecb \u1ea3nh h\u01b0\u1edfng, n\u00e2ng cao hi\u1ec7u qu\u1ea3 c\u1ee7a ch\u00fang. C\u00e1c h\u1ea1t nano v\u00e0ng ho\u1eb7c selen gi\u1ea3m s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a c\u00e1c protein \u0111\u1ed9c h\u1ea1i v\u00e0 c\u0103ng th\u1eb3ng oxy h\u00f3a trong b\u1ec7nh Alzheimer v\u00e0 Parkinson.<\/p>\n Vi\u1ec7c \u0111\u1ecbnh v\u1ecb l\u1ea1i c\u00e1c thu\u1ed1c hi\u1ec7n c\u00f3 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh ph\u00e1t hi\u1ec7n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb. C\u00e1c ph\u00e2n t\u1eed ban \u0111\u1ea7u \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n cho c\u00e1c b\u1ec7nh kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 ambroxol cho c\u00e1c b\u1ec7nh h\u00f4 h\u1ea5p, cho th\u1ea5y t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh ch\u1ed1ng l\u1ea1i b\u1ec7nh Parkinson. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y gi\u1ea3m chi ph\u00ed v\u00e0 th\u1eddi gian ph\u00e1t tri\u1ec3n, \u0111\u1ed3ng th\u1eddi mang l\u1ea1i nh\u1eefng gi\u1ea3i ph\u00e1p nhanh ch\u00f3ng cho b\u1ec7nh nh\u00e2n.<\/p>\n Cu\u1ed1i c\u00f9ng, c\u00e1c k\u1ef9 thu\u1eadt nh\u01b0 k\u00edch th\u00edch n\u00e3o s\u00e2u cho ph\u00e9p \u0111i\u1ec1u ch\u1ec9nh ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u01a1-ron th\u00f4ng qua c\u00e1c xung \u0111i\u1ec7n, c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1eadn \u0111\u1ed9ng trong b\u1ec7nh Parkinson. Nh\u1eefng ti\u1ebfn b\u1ed9 trong tr\u00ed tu\u1ec7 nh\u00e2n t\u1ea1o v\u00e0 ph\u00e1t hi\u1ec7n c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc m\u1edf ra con \u0111\u01b0\u1eddng ch\u1ea9n \u0111o\u00e1n s\u1edbm h\u01a1n v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00e1 nh\u00e2n h\u00f3a, ph\u00f9 h\u1ee3p v\u1edbi \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n.<\/p>\n “`<\/p>\n DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1186\/s13064-026-00279-0<\/a><\/p>\n Titre\u00a0:<\/strong> Advances in neurotherapeutics for neurodegeneration<\/p>\n Revue : <\/strong> Discover Neuroscience<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Daksh Kapur; Deeti Vashisht; Taru Singh<\/p>\n","protected":false},"excerpt":{"rendered":" “`html C\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh l\u00f9i b\u01b0\u1edbc tr\u01b0\u1edbc nh\u1eefng ti\u1ebfn b\u1ed9 \u0111i\u1ec1u tr\u1ecb C\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh nh\u01b0 Alzheimer, Parkinson v\u00e0 x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (ALS) \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng tri\u1ec7u ng\u01b0\u1eddi tr\u00ean th\u1ebf gi\u1edbi. S\u1ef1 ti\u1ebfn tri\u1ec3n ch\u1eadm c\u1ee7a ch\u00fang v\u00e0 thi\u1ebfu c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7t… Continue reading C\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh l\u00f9i b\u01b0\u1edbc tr\u01b0\u1edbc nh\u1eefng ti\u1ebfn b\u1ed9 \u0111i\u1ec1u tr\u1ecb<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,2],"tags":[],"class_list":["post-36","post","type-post","status-publish","format-standard","hentry","category-quoc-te","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/posts\/36","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/comments?post=36"}],"version-history":[{"count":1,"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/posts\/36\/revisions"}],"predecessor-version":[{"id":37,"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/posts\/36\/revisions\/37"}],"wp:attachment":[{"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/media?parent=36"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/categories?post=36"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/vi\/wp-json\/wp\/v2\/tags?post=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nSources du m\u00e9dia<\/h2>\n
Document de r\u00e9f\u00e9rence<\/h3>\n