Ottoizm, \u015fizofreni, Alzheimer hastal\u0131\u011f\u0131 veya epilepsi gibi beyin hastal\u0131klar\u0131n\u0131n karma\u015f\u0131k genetik k\u00f6kenleri vard\u0131r. \u015eu ana kadar bilim insanlar\u0131, bu bozukluklarla ili\u015fkili hem s\u0131k hem de nadir g\u00f6r\u00fclen genetik varyasyonlar\u0131 belirlemi\u015ftir. Bununla birlikte, bu iki t\u00fcr varyasyonun etkiledi\u011fi ortak biyolojik s\u00fcre\u00e7ler hala yeterince anla\u015f\u0131lmam\u0131\u015ft\u0131r.<\/p>\n
Yeni bir yakla\u015f\u0131m, 933 adet \u00f6l\u00fcm sonras\u0131 beyin \u00f6rne\u011finde gen ifadesini analiz ederek bu mekanizmalar\u0131 ayd\u0131nlatmay\u0131 ba\u015fard\u0131. Ara\u015ft\u0131rmac\u0131lar, s\u0131k ve nadir varyasyonlar \u00fczerine yap\u0131lan \u00e7al\u0131\u015fmalarda genellikle farkl\u0131 risk genleri olmas\u0131na ra\u011fmen, bu risk genleriyle koordineli \u015fekilde ifade edilen genlerin \u00f6nemli \u00f6l\u00e7\u00fcde \u00f6rt\u00fc\u015ft\u00fc\u011f\u00fcn\u00fc ke\u015ffetti. Bu ortak genler, hem s\u0131k hem de nadir varyasyonlar i\u00e7in hastal\u0131klar\u0131n kal\u0131tsall\u0131\u011f\u0131nda g\u00fc\u00e7l\u00fc bir rol oynamaktad\u0131r.<\/p>\n
\u00c7al\u0131\u015fma ayr\u0131ca, bu genlerin \u00f6nemli ortak \u00f6zelliklere sahip oldu\u011funu da ortaya koyuyor: mutasyonlara daha duyarl\u0131d\u0131rlar ve mevcut ila\u00e7lar taraf\u0131ndan daha s\u0131k hedeflenirler. Bu da onlar\u0131n yeni tedavilerin geli\u015ftirilmesinde kilit bir rol oynayabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Ayr\u0131ca, n\u00f6ronlar aras\u0131ndaki ileti\u015fim veya ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 gibi bir\u00e7ok psikiyatrik bozuklukta bozulmu\u015f olan temel biyolojik s\u00fcre\u00e7lerde yer almaktad\u0131rlar.<\/p>\n
Son olarak, bu ara\u015ft\u0131rma, \u00f6zellikle astrositler ve glutamaterjik n\u00f6ronlar gibi beynin belirli h\u00fccre tiplerinin \u00f6zellikle etkilenmi\u015f oldu\u011funu ortaya \u00e7\u0131karmaktad\u0131r. Bu sonu\u00e7lar, beyin hastal\u0131klar\u0131n\u0131n alt\u0131ndaki mekanizmalar\u0131n daha iyi anla\u015f\u0131lmas\u0131na yol a\u00e7abilir ve yeni terap\u00f6tik hedeflerin belirlenmesine yard\u0131mc\u0131 olabilir.<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41380-026-03571-x<\/a><\/p>\n Titre\u00a0:<\/strong> Convergent coexpression reveals shared biological mechanisms underlying common and rare variant risk in six neuropsychiatric disorders<\/p>\n Revue : <\/strong> Molecular Psychiatry<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Hanna Abe; Calwing Liao; Lide Han; Theodore Morley; Michael E. Talkowski; Kristen J. Brennand; Douglas M. Ruderfer<\/p>\n","protected":false},"excerpt":{"rendered":" Psikiyatrik bozukluklar ortak biyolojik mekanizmalara sahip mi? Ottoizm, \u015fizofreni, Alzheimer hastal\u0131\u011f\u0131 veya epilepsi gibi beyin hastal\u0131klar\u0131n\u0131n karma\u015f\u0131k genetik k\u00f6kenleri vard\u0131r. \u015eu ana kadar bilim insanlar\u0131, bu bozukluklarla ili\u015fkili hem s\u0131k hem de nadir g\u00f6r\u00fclen genetik varyasyonlar\u0131 belirlemi\u015ftir. Bununla birlikte, bu iki t\u00fcr varyasyonun etkiledi\u011fi ortak biyolojik s\u00fcre\u00e7ler hala yeterince anla\u015f\u0131lmam\u0131\u015ft\u0131r. Yeni bir yakla\u015f\u0131m, 933 adet… Okumaya devam et Psikiyatrik bozukluklar ortak biyolojik mekanizmalara sahip mi?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-27","post","type-post","status-publish","format-standard","hentry","category-saglik","entry"],"_links":{"self":[{"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/posts\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/comments?post=27"}],"version-history":[{"count":1,"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/posts\/27\/revisions"}],"predecessor-version":[{"id":28,"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/posts\/27\/revisions\/28"}],"wp:attachment":[{"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/media?parent=27"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/categories?post=27"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/tr\/wp-json\/wp\/v2\/tags?post=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}