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\"\uc2e0\uacbd\ubcc0\uc131“`html<\/p>\n

\uc2e0\uacbd\ubcc0\uc131 \uc9c8\ud658, \uce58\ub8cc \ubc1c\uc804\uc73c\ub85c \ud6c4\ud1f4<\/h1>\n

\uc54c\uce20\ud558\uc774\uba38, \ud30c\ud0a8\uc2a8\ubcd1, \uadfc\uc704\ucd95\uc131 \uce21\uc0c9\uacbd\ud654\uc99d(ALS)\uacfc \uac19\uc740 \uc2e0\uacbd\ubcc0\uc131 \uc9c8\ud658\uc740 \uc804 \uc138\uacc4 \uc218\ubc31\ub9cc \uba85\uc5d0\uac8c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc9c8\ud658\uc740 \uc9c4\ud589\uc774 \ub290\ub9ac\uace0, \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc\uc81c\uac00 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \uacf5\uc911\ubcf4\uac74\uc758 \uc8fc\uc694 \uacfc\uc81c\uac00 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc9c8\ud658\ub4e4\uc740 \uacf5\ud1b5\ub41c \uba54\ucee4\ub2c8\uc998\uc744 \uacf5\uc720\ud569\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc7a5\uc560, \ube44\uc815\uc0c1\uc801\uc778 \ub2e8\ubc31\uc9c8 \ucd95\uc801, \uc138\ud3ec\uace8\uaca9 \uc7a5\uc560, \uc2dc\ub0c5\uc2a4 \uae30\ub2a5 \uc800\ud558, \uc2e0\uacbd\uacc4\uc758 \ub9cc\uc131 \uc5fc\uc99d \ub4f1\uc774 \uadf8 \uc608\uc785\ub2c8\ub2e4.<\/p>\n

\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0\uc11c\ub294 \ubca0\ud0c0\uc544\ubc00\ub85c\uc774\ub4dc \ud3a9\ud2f0\ub4dc\uac00 \ucd95\uc801\ub418\uc5b4 \ud50c\ub77c\ud06c\ub97c \ud615\uc131\ud558\uace0, \uc774\ub294 \uc2e0\uacbd \uc138\ud3ec \uac04\uc758 \uc758\uc0ac\uc18c\ud1b5\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud50c\ub77c\ud06c\ub294 \ub1cc\uc758 \uba74\uc5ed \uc138\ud3ec\uc778 \ubbf8\uc138\uc544\uad50\uc138\ud3ec\uc640 \ubcc4\uc544\uad50\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc9c0\uc18d\uc801\uc778 \uc5fc\uc99d\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc774 \ubc18\uc751\uc740 \uc2dc\ub0c5\uc2a4\uc758 \uc190\uc0c1\uc744 \uc545\ud654\uc2dc\ud0a4\uace0, \ud0c0\uc6b0 \ub2e8\ubc31\uc9c8 \uc794\ud574\uc758 \ud615\uc131\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \ud0c0\uc6b0 \ub2e8\ubc31\uc9c8 \uc794\ud574\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ub610 \ub2e4\ub978 \ud2b9\uc9d5\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacfc\uc815\ub4e4\uc740 \uae30\uc5b5\ub825\uacfc \uc778\uc9c0 \ub2a5\ub825\uc758 \uc810\uc9c4\uc801\uc778 \uc190\uc2e4\uc744 \ucd08\ub798\ud558\uc5ec, \uc77c\uc0c1 \uc0dd\ud65c\uc774 \uc810\uc810 \uc5b4\ub824\uc6cc\uc9d1\ub2c8\ub2e4.<\/p>\n

\ud30c\ud0a8\uc2a8\ubcd1\uc740 \ub5a8\ub9bc, \uc6b4\ub3d9 \ub290\ub9bc, \uade0\ud615 \uc7a5\uc560\ub85c \ub098\ud0c0\ub0a9\ub2c8\ub2e4. \uc774\ub294 \ub1cc\uc758 \ud751\uc9c8\uc774\ub77c\ub294 \uc601\uc5ed\uc5d0\uc11c \ub3c4\ud30c\ubbfc\uc744 \uc0dd\uc131\ud558\ub294 \uc2e0\uacbd \uc138\ud3ec\uc758 \ud1f4\ud654\ub85c \uc778\ud574 \ubc1c\uc0dd\ud569\ub2c8\ub2e4. \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778 \ub2e8\ubc31\uc9c8\uc758 \uc751\uc9d1\uccb4\uc778 \ub974\uc704\uccb4(Lewy body)\uac00 \ub3c4\ud30c\ubbfc \uc0dd\uc131\uacfc \uc2e0\uacbd \uc2e0\ud638 \uc804\ub2ec\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4. \ub610\ud55c, PINK1\uc774\ub098 Parkin\uacfc \uac19\uc740 \uc720\uc804\uc790 \ubcc0\uc774\uac00 \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uc81c\uac70\ub97c \ubc29\ud574\ud558\uc5ec \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc138\ud3ec \uc0ac\ub9dd\uc744 \uc545\ud654\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\uadfc\uc704\ucd95\uc131 \uce21\uc0c9\uacbd\ud654\uc99d(ALS)\uc740 \uc6b4\ub3d9 \uc2e0\uacbd \uc138\ud3ec\ub97c \uacf5\uaca9\ud558\uc5ec \uc810\uc9c4\uc801\uc778 \uadfc\ub825 \uc57d\ud654\uc640 \ub9c8\ube44\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4. SOD1\uc774\ub098 TDP-43\uacfc \uac19\uc740 \ub3c5\uc131 \ub2e8\ubc31\uc9c8\uc758 \ucd95\uc801\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc7a5\uc560\ub97c \uc77c\uc73c\ud0a4\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c, \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\uc778 \uae00\ub8e8\ud0c0\uba54\uc774\ud2b8\uc758 \uacfc\ub2e4 \ubd84\ube44\ub294 NMDA\uc640 AMPA \uc218\uc6a9\uccb4\ub97c \uacfc\ub3c4\ud558\uac8c \uc790\uadf9\ud558\uc5ec \uc138\ud3ec \ub0b4\ub85c \ub300\ub7c9\uc758 \uce7c\uc298\uc774 \uc720\uc785\ub429\ub2c8\ub2e4. \uc774 \ubbf8\ub124\ub784 \ubd88\uade0\ud615\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \uc190\uc0c1\uc2dc\ud0a4\uace0 \uc2e0\uacbd \uc138\ud3ec\uc758 \ud1f4\ud654\ub97c \uac00\uc18d\ud654\ud569\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac \uce58\ub8cc\ubc95\uc740 \uc8fc\ub85c \uc99d\uc0c1\uc744 \uc644\ud654\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \uacbd\uc6b0, \uac08\ub780\ud0c0\ubbfc\uacfc \uac19\uc740 \uc544\uc138\ud2f8\ucf5c\ub9b0\uc5d0\uc2a4\ud14c\ub77c\uc544\uc81c \uc5b5\uc81c\uc81c\uac00 \uae30\uc5b5\uc5d0 \uc911\uc694\ud55c \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\uc778 \uc544\uc138\ud2f8\ucf5c\ub9b0\uc758 \uc218\uc900\uc744 \uc720\uc9c0\ud569\ub2c8\ub2e4. NMDA \uc218\uc6a9\uccb4 \uae38\ud56d\uc81c\uc778 \uba54\ub9cc\ud2f4\uc740 \uc2e0\uacbd \uc138\ud3ec \ub0b4 \uce7c\uc298 \uacfc\uc789\uc744 \uc81c\ud55c\ud558\uc5ec \ub3c5\uc131\uc744 \uc904\uc785\ub2c8\ub2e4. \ud30c\ud0a8\uc2a8\ubcd1\uc5d0\uc11c\ub294 L-DOPA\uac00 \ub3c4\ud30c\ubbfc \ubd80\uc871\uc744 \ubcf4\uc644\ud558\uace0, \ub3c4\ud30c\ubbfc \uc791\uc6a9\uc81c\ub294 \ub3c4\ud30c\ubbfc\uc758 \uc5ed\ud560\uc744 \ubaa8\ubc29\ud569\ub2c8\ub2e4. \uadfc\uc704\ucd95\uc131 \uce21\uc0c9\uacbd\ud654\uc99d\uc758 \uacbd\uc6b0, \ub9b4\ub8e8\uc878\uc740 \uae00\ub8e8\ud0c0\uba54\uc774\ud2b8 \uacfc\uc789\uc744 \uc904\uc5ec \uc2e0\uacbd \uc138\ud3ec\ub97c \ubd80\ubd84\uc801\uc73c\ub85c \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/p>\n

\ud601\uc2e0\uc801\uc778 \uc811\uadfc \ubc29\uc2dd\uc740 \uc0c8\ub85c\uc6b4 \uac00\ub2a5\uc131\uc744 \uc5f4\uc5b4\uc90d\ub2c8\ub2e4. \uba74\uc5ed \uc694\ubc95\uc740 \ub3c5\uc131 \ub2e8\ubc31\uc9c8 \uc751\uc9d1\uccb4\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub97c \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \ub808\uce74\ub124\ub9d9\uc774\ub098 \uc544\ub450\uce74\ub204\ub9d9\uacfc \uac19\uc740 \ud56d\uccb4\ub294 \ubca0\ud0c0\uc544\ubc00\ub85c\uc774\ub4dc \ud50c\ub77c\ud06c\uc5d0 \uacb0\ud569\ud558\uc5ec \uba74\uc5ed \uc138\ud3ec\uac00 \uc774\ub97c \uc81c\uac70\ud560 \uc218 \uc788\ub3c4\ub85d \ub3d5\uc2b5\ub2c8\ub2e4. \ud30c\ud0a8\uc2a8\ubcd1\uc758 \uacbd\uc6b0, \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \ud504\ub77c\uc2dc\ub124\ub9d9\uacfc \uac19\uc740 \ud56d\uccb4\uac00 \ud1f4\ud654\ub97c \uc77c\uc73c\ud0a4\ub294 \uc751\uc9d1\uccb4\ub97c \uc911\ud654\uc2dc\ud0a4\ub294 \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4.<\/p>\n

\uc720\uc804\uc790 \uce58\ub8cc\ub294 \uc774\ub7ec\ud55c \uc9c8\ud658\uc758 \uc6d0\uc778\uc774 \ub418\ub294 \uc720\uc804\uc801 \uc774\uc0c1\uc744 \uad50\uc815\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4. \ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130\uac00 \uce58\ub8cc\uc6a9 \uc720\uc804\uc790\ub97c \ub1cc\ub85c \uc804\ub2ec\ud558\uc5ec \uc2e0\uacbd \uc138\ud3ec\uc758 \uc0dd\uc874\uc744 \uc9c0\uc6d0\ud558\uace0, \ub3c5\uc131 \ub2e8\ubc31\uc9c8\uc758 \ucd95\uc801\uc744 \uc904\uc774\uac70\ub098 \uc5fc\uc99d\uc744 \uc870\uc808\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, NGF\ub098 BDNF\uc640 \uac19\uc740 \uc720\uc804\uc790\ub294 \uc2e0\uacbd \uc138\ud3ec\uc758 \uc131\uc7a5\uacfc \ubcf4\ud638\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uadfc\uc704\ucd95\uc131 \uce21\uc0c9\uacbd\ud654\uc99d\uc758 \uacbd\uc6b0, \uc720\uc804\uc790 \uce68\ubb35\ud654 \uae30\uc220\uc774 \ubcc0\uc774 \uc788\ub294 SOD1\uc774\ub098 C9ORF72 \uc720\uc804\uc790\ub97c \ud45c\uc801\uc73c\ub85c \ud558\uc5ec \uc720\ud574\ud55c \ub2e8\ubc31\uc9c8\uc758 \uc0dd\uc131\uc744 \uc904\uc785\ub2c8\ub2e4.<\/p>\n

\ucc9c\uc5f0 \ud654\ud569\ubb3c\ub3c4 \uc720\ub9dd\ud55c \ud574\uacb0\ucc45\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub208\uc18d\uc5d0\uc11c \ucd94\ucd9c\ub41c \uac08\ub780\ud0c0\ubbfc\uc740 \uc544\uc138\ud2f8\ucf5c\ub9b0\uc5d0\uc2a4\ud14c\ub77c\uc544\uc81c\ub97c \uc5b5\uc81c\ud558\uc5ec \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \uc99d\uc0c1\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4. \ucee4\ud050\ubbfc\uacfc \uc2e4\ub9ac\ub9c8\ub9b0\uc740 \ud56d\uc5fc\uc99d \ubc0f \ud56d\uc0b0\ud654 \ud2b9\uc131\uc744 \ud1b5\ud574 \ub2e8\ubc31\uc9c8 \uc751\uc9d1\uc744 \uc81c\ud55c\ud558\uace0 \uc2e0\uacbd \uc138\ud3ec\ub97c \ubcf4\ud638\ud569\ub2c8\ub2e4. Mucuna pruriens<\/em>\ub294 L-DOPA\uac00 \ud48d\ubd80\ud558\uc5ec \ud30c\ud0a8\uc2a8\ubcd1\uc758 \uc99d\uc0c1\uc744 \uc644\ud654\ud558\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc904\uc785\ub2c8\ub2e4. \ub2c8\uc544\uc2e0(\ube44\ud0c0\ubbfc B3)\uc740 \ub3c4\ud30c\ubbfc \uc0dd\uc131\uc744 \uc790\uadf9\ud558\uace0 \uc5ec\ub7ec \uc2e0\uacbd\ubcc0\uc131 \uc9c8\ud658\uc5d0\uc11c \uc6b4\ub3d9 \uae30\ub2a5\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/p>\n

\ub098\ub178 \uae30\uc220\uc740 \uc57d\ubb3c \uc804\ub2ec\uc744 \ud601\uc2e0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc720\uae30 \ub610\ub294 \ubb34\uae30 \ub098\ub178 \uc785\uc790\ub294 \ud608\uc561-\ub1cc \uc7a5\ubcbd\uc744 \ud1b5\uacfc\ud558\uc5ec, \uc804\ud1b5\uc801\uc778 \uce58\ub8cc\ubc95\uc758 \uc8fc\uc694 \uc7a5\uc560\ubb3c\uc744 \uadf9\ubcf5\ud569\ub2c8\ub2e4. \uc904\uae30 \uc138\ud3ec\uc5d0\uc11c \uc720\ub798\ud55c \uc791\uc740 \uc18c\ud3ec\uc778 \uc5d1\uc18c\uc880\uc740 \uc5fc\uc99d\uc744 \uc870\uc808\ud558\uace0 \uc2e0\uacbd \uc7ac\uc0dd\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc9c0\uc9c8 \ub098\ub178 \uc785\uc790\ub294 \uc57d\ubb3c\uc744 \ubcf4\ud638\ud558\uace0 \uc601\ud5a5\uc744 \ubc1b\uc740 \ubd80\uc704\ub85c \uc9c1\uc811 \uc804\ub2ec\ud558\uc5ec \ud6a8\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uae08\uc774\ub098 \uc140\ub808\ub284 \ub098\ub178 \uc785\uc790\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \ud30c\ud0a8\uc2a8\ubcd1\uc5d0\uc11c \ub3c5\uc131 \ub2e8\ubc31\uc9c8\uc758 \ucd95\uc801\uacfc \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc904\uc785\ub2c8\ub2e4.<\/p>\n

\uae30\uc874 \uc57d\ubb3c\uc758 \uc7ac\uc0ac\uc6a9\uc740 \uce58\ub8cc\uc81c \ubc1c\uacac\uc744 \uac00\uc18d\ud654\ud569\ub2c8\ub2e4. \uc6d0\ub798 \ub2e4\ub978 \uc9c8\ud658\uc744 \uc704\ud574 \uac1c\ubc1c\ub41c \ubd84\uc790, \uc608\ub97c \ub4e4\uc5b4 \ud638\ud761\uae30 \uc9c8\ud658\uc744 \uc704\ud55c \uc554\ube0c\ub85d\uc194\uc740 \ud30c\ud0a8\uc2a8\ubcd1\uc5d0 \ub300\ud55c \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\ub97c \ubcf4\uc785\ub2c8\ub2e4. \uc774 \uc811\uadfc \ubc29\uc2dd\uc740 \ube44\uc6a9\uacfc \uac1c\ubc1c \uc2dc\uac04\uc744 \uc904\uc774\uba74\uc11c \ud658\uc790\ub4e4\uc5d0\uac8c \uc2e0\uc18d\ud55c \ud574\uacb0\ucc45\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ub9c8\uc9c0\ub9c9\uc73c\ub85c, \ub1cc \uc2ec\ubd80 \uc790\uadf9\uacfc \uac19\uc740 \uae30\uc220\uc740 \uc804\uae30\uc801 \uc790\uadf9\uc744 \ud1b5\ud574 \uc2e0\uacbd \ud65c\ub3d9\uc744 \uc870\uc808\ud558\uc5ec \ud30c\ud0a8\uc2a8\ubcd1\uc758 \uc6b4\ub3d9 \uc99d\uc0c1\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4. \uc778\uacf5 \uc9c0\ub2a5\uacfc \uc0dd\uccb4 \ud45c\uc9c0\uc790 \ubc1c\uacac\uc758 \ubc1c\uc804\uc740 \uc870\uae30 \uc9c4\ub2e8\uacfc \uac01 \ud658\uc790\uc758 \ud2b9\uc131\uc5d0 \ub9de\ucd98 \ub9de\ucda4\ud615 \uce58\ub8cc\uc758 \uae38\uc744 \uc5f4\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

“`<\/p>\n

\n

Sources du m\u00e9dia<\/h2>\n

Document de r\u00e9f\u00e9rence<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1186\/s13064-026-00279-0<\/a><\/p>\n

Titre\u00a0:<\/strong> Advances in neurotherapeutics for neurodegeneration<\/p>\n

Revue : <\/strong> Discover Neuroscience<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Daksh Kapur; Deeti Vashisht; Taru Singh<\/p>\n","protected":false},"excerpt":{"rendered":"

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