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“`html<\/p>\n

\uc790\ud3d0 \uc2a4\ud399\ud2b8\ub7fc \uc7a5\uc560\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \ubbf8\uc0dd\ubb3c\uad70 \ubc0f \uc57d\ubb3c \uce58\ub8cc\uac00 \uc720\ub9dd\ud55c \uacb0\uacfc \ubcf4\uc784<\/h1>\n

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\ucd5c\uadfc \uccb4\uacc4\uc801 \uac80\ud1a0\uc5d0\uc11c 2010\ub144\uc5d0\uc11c 2025\ub144 \uc0ac\uc774\uc5d0 \ubc1c\ud45c\ub41c 52\uac74\uc758 \uc5f0\uad6c\ub97c \ubd84\uc11d\ud558\uc5ec, \uc57d\ubb3c \uce58\ub8cc \ubc0f \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uad70 \ud45c\uc801 \uce58\ub8cc\uc758 \ud6a8\uacfc\ub97c \ud0d0\uad6c\ud588\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\ub41c \uc911\uc7ac\uc5d0\ub294 \uc625\uc2dc\ud1a0\uc2e0 \uc81c\uc81c, \uc2e0\uacbd \ud765\ubd84\uacfc \uc5b5\uc81c \uade0\ud615\uc744 \uc870\uc808\ud558\ub294 \uc57d\ubb3c, \uce78\ub098\ube44\ub178\uc774\ub4dc, \ud478\ub9b0, \uadf8\ub9ac\uace0 \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4, \ud504\ub9ac\ubc14\uc774\uc624\ud2f1\uc2a4, \ub300\ubcc0 \uc774\uc2dd\uacfc \uac19\uc740 \ubbf8\uc0dd\ubb3c\uad70 \uae30\ubc18 \uc804\ub7b5\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc811\uadfc\ubc95\ub4e4\uc740 \uc2e0\uacbd\uc804\ub2ec, \uc2e0\uacbd\uc5fc\uc99d, \ub300\uc0ac, \uc7a5-\ub1cc \ucd95\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \uc2dc\uc2a4\ud15c\uc744 \uc870\uc808\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4.<\/p>\n

\uacb0\uacfc\uc5d0 \ub530\ub974\uba74, \uc790\ud3d0 \uc2a4\ud399\ud2b8\ub7fc \uc7a5\uc560\uc640 \uad00\ub828\ub41c \ud589\ub3d9 \uacb0\ud54d\uc740 \uc784\uc0c1 \uc804 \ubaa8\ub378\uc5d0\uc11c \uc774\ub7ec\ud55c \uc2dc\uc2a4\ud15c\uc744 \ud45c\uc801\ud654\ud55c \uc911\uc7ac\ub97c \ud1b5\ud574 \uc644\ud654\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc0ac\ud68c\uc801 \ud589\ub3d9 \uc870\uc808\uc5d0 \uad00\uc5ec\ud558\ub294 \ud638\ub974\ubaac\uc778 \uc625\uc2dc\ud1a0\uc2e0\uc740 \uc5ec\ub7ec \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \uc0ac\ud68c\uc131 \ud5a5\uc0c1\uacfc \ubc18\ubcf5\uc801 \ud589\ub3d9 \uac10\uc18c\uc5d0 \uae0d\uc815\uc801\uc778 \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uadf8 \ud6a8\uacfc\ub294 \uce58\ub8cc \uacc4\ud68d, \ubc1c\uc804 \ub2e8\uacc4, \ub3d9\ubb3c\uc758 \uc131\ubcc4 \ubc0f \uc0ac\uc6a9\ub41c \ud2b9\uc815 \ubaa8\ub378\uc5d0 \ub530\ub77c \ub2e4\ub985\ub2c8\ub2e4. \uc77c\ubd80 \uacbd\uc6b0\uc5d0\uc11c \uc625\uc2dc\ud1a0\uc2e0\uc740 \ubc18\ubcf5\uc801 \ud589\ub3d9\uc5d0 \uc544\ubb34\ub7f0 \ud6a8\uacfc\ub97c \ubcf4\uc774\uc9c0 \uc54a\uac70\ub098 \uc624\ud788\ub824 \uc545\ud654\uc2dc\ud0a4\uae30\ub3c4 \ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc625\uc2dc\ud1a0\uc2e0 \uc218\uc6a9\uccb4 \uae38\ud56d\uc81c\uc640 \uac19\uc740 \ub2e4\ub978 \uc911\uc7ac\ub4e4\ub3c4 \uc720\ub9dd\ud55c \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc625\uc2dc\ud1a0\uc2e0 \uc218\uc6a9\uccb4 \uae38\ud56d\uc81c\uc778 \uc544\ud1a0\uc2dc\ubc18\uc740 \uc784\uc2e0 \uc911 \ubc1c\ud504\ub85c\uc0b0\uc5d0 \ub178\ucd9c\ub41c \uc554\ucef7 \uc950\uc5d0\uc11c \uc0ac\ud68c\uc801 \uacb0\ud568, \ubd88\uc548, \ubc18\ubcf5\uc801 \ud589\ub3d9\uc744 \uac1c\uc120\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ub180\ub78d\uace0\ub3c4 \ud765\ubbf8\ub85c\uc6b4 \uacb0\uacfc\ub294 \uc77c\ubd80 \uacbd\uc6b0\uc5d0\uc11c \uc625\uc2dc\ud1a0\uc2e0 \uc2dc\uc2a4\ud15c\uc758 \uacfc\ub3c4\ud55c \ud65c\uc131\uc774 \uc99d\uc0c1\uc744 \uc545\ud654\uc2dc\ud0ac \uc218 \uc788\uc73c\uba70, \uae38\ud56d\uc81c\uac00 \uc720\uc775\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\uc2e0\uacbd \ud765\ubd84\uacfc \uc5b5\uc81c \uade0\ud615\uc744 \ud45c\uc801\ud654\ud55c \uce58\ub8cc\ubc95\ub4e4\ub3c4 \uace0\ubb34\uc801\uc778 \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, NMDA \uc218\uc6a9\uccb4 \uae38\ud56d\uc81c\uc778 \uba54\ub9cc\ud2f4\uc740 \ubc1c\ud504\ub85c\uc0b0\uc5d0 \ub178\ucd9c\ub41c \uc950\uc5d0\uc11c \uc0ac\ud68c\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ubc18\ubcf5\uc801 \ud589\ub3d9\uc744 \uac10\uc18c\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \ub610\ud55c, mGlu5 \uc218\uc6a9\uccb4\uc758 \uc591\uc131 \ubcc0\ud615 \uc870\uc808\uc81c\uc778 CDPPB\ub294 \uc790\ud3d0 \uc2a4\ud399\ud2b8\ub7fc \uc7a5\uc560\uc758 \uc720\uc804\uc801 \ubaa8\ub378\uc5d0\uc11c \ud589\ub3d9 \uacb0\ud568\uc744 \uc644\ud654\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uad70 \uae30\ubc18 \uc911\uc7ac\ub294 \ud601\uc2e0\uc801\uc778 \uc811\uadfc\ubc95\uc785\ub2c8\ub2e4. \ub300\ubcc0 \uc774\uc2dd\uacfc Bifidobacterium longum<\/em>\uacfc \uac19\uc740 \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4\ub294 \uc0ac\ud68c\uc801 \ud589\ub3d9 \uac1c\uc120\uacfc \ubd88\uc548 \uac10\uc18c\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc911\uc7ac\ub294 \uc7a5\ub0b4 \ub300\uc0ac\ub97c \uc870\uc808\ud558\uace0 \uc7a5-\ub1cc \uc18c\ud1b5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, Bifidobacterium longum<\/em> \ud22c\uc5ec\ub294 \ud2b8\ub9bd\ud1a0\ud310 \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \ud0a4\ub204\ub808\ub2cc \uc218\uce58\ub97c \uac10\uc18c\uc2dc\ucf30\uc73c\uba70, \uc774\ub294 \uc2e0\uacbd\uc804\ub2ec\uacfc \uc5fc\uc99d\uacfc \uad00\ub828\ub41c \ub300\uc0ac\ubb3c\uc9c8\uc785\ub2c8\ub2e4.<\/p>\n

\uba54\ud2b8\ud3ec\ub974\ubbfc\uacfc \ud53c\uc624\uae00\ub9ac\ud0c0\uc874\uacfc \uac19\uc740 \ub300\uc0ac \uce58\ub8cc\ubc95\ub3c4 \uae0d\uc815\uc801\uc778 \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc774 \uc57d\ubb3c\ub4e4\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ub2f9\ub1e8 \uce58\ub8cc\uc5d0 \uc0ac\uc6a9\ub418\uc9c0\ub9cc, \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \uc0ac\ud68c\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ubc18\ubcf5\uc801 \ud589\ub3d9\uc744 \uac10\uc18c\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \uc774\ub4e4\uc758 \ud6a8\uacfc\ub294 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc2e0\uacbd\uc5fc\uc99d \uac10\uc18c\ub97c \ud1b5\ud574 \ub9e4\uac1c\ub418\ub294 \uac83\uc73c\ub85c \ubcf4\uc774\uba70, \uc774\ub294 \uc790\ud3d0 \uc2a4\ud399\ud2b8\ub7fc \uc7a5\uc560\uc5d0\uc11c \ud754\ud788 \uad50\ub780\ub418\ub294 \uba54\ucee4\ub2c8\uc998\uc785\ub2c8\ub2e4.<\/p>\n

\uce78\ub098\ube44\ub178\uc774\ub4dc\uc778 \uce78\ub098\ube44\ub514\uc62c\uacfc \ud14c\ud2b8\ub77c\ud558\uc774\ub4dc\ub85c\uce78\ub098\ube44\ub180\ub3c4 \uc5f0\uad6c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubcf5\uc6a9\ub7c9\uc5d0 \ub530\ub77c \ud6a8\uacfc\uac00 \ub2e4\ub974\uc9c0\ub9cc, \uc77c\ubd80 \uc81c\ud615\uc740 \uc0ac\ud68c\uc801 \ud589\ub3d9 \uac1c\uc120\uacfc \ubc18\ubcf5\uc801 \ud589\ub3d9 \uac10\uc18c\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uce78\ub098\ube44\ub514\uc62c\uc774 \ud48d\ubd80\ud55c \uc544\ube44\ub370\ucf08 \uc624\uc77c\uc740 \uc950\uc5d0\uc11c \uadf8\ub8e8\ubc0d \uc2dc\uac04\uc744 \uc904\uc774\uace0 \uc0ac\ud68c\uc131\uc744 \ud5a5\uc0c1\uc2dc\ucf30\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud478\ub9b0 \uc2dc\uc2a4\ud15c\uc744 \ud45c\uc801\ud654\ud55c \uc911\uc7ac\uc778 \uc218\ub77c\ubbfc\ub3c4 \uc720\uc775\ud55c \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc218\ub77c\ubbfc\uc740 \ud478\ub9b0 \uae38\ud56d\uc81c\ub85c, \ubaa8\uccb4 \uba74\uc5ed \ud65c\uc131\ud654\ub098 \uc784\uc2e0 \uc911 \ubc1c\ud504\ub85c\uc0b0 \ub178\ucd9c\ub85c \uc720\ubc1c\ub41c \uc790\ud3d0 \uc2a4\ud399\ud2b8\ub7fc \uc7a5\uc560 \ubaa8\ub378\uc5d0\uc11c \uc0ac\ud68c\uc801 \ud589\ub3d9 \uac1c\uc120\uacfc \ubd88\uc548 \uac10\uc18c\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub9c8\uc9c0\ub9c9\uc73c\ub85c, \ube44\ud0c0\ubbfc D3\uacfc \ub808\ud2f0\ub178\uc0b0\uacfc \uac19\uc740 \ube44\ud0c0\ubbfc\ub4e4\ub3c4 \uc720\ub9dd\ud55c \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub808\ud2f0\ub178\uc0b0\uc740 \ubc1c\ud504\ub85c\uc0b0\uc5d0 \ub178\ucd9c\ub41c \uc950\uc5d0\uc11c \uc0ac\ud68c\uc801 \ud589\ub3d9\uc744 \uac1c\uc120\ud558\uace0 \ubc18\ubcf5\uc801 \ud589\ub3d9\uc744 \uac10\uc18c\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud6a8\uacfc\ub294 \ubbf8\uc138\uc544\uad50\uc138\ud3ec \ud65c\uc131\ud654\uc640 \uc2e0\uacbd\uc5fc\uc99d \uc870\uc808\uc744 \ud1b5\ud574 \ub9e4\uac1c\ub418\ub294 \uac83\uc73c\ub85c \ubcf4\uc785\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uacb0\uacfc\ub4e4\uc740 \uc790\ud3d0 \uc2a4\ud399\ud2b8\ub7fc \uc7a5\uc560\uac00 \ub2e8\uc21c \ubd84\uc790 \uacb0\ud568\ubcf4\ub2e4\ub294 \uc0c1\ud638\uc791\uc6a9\ud558\ub294 \uc2dc\uc2a4\ud15c \uacfc\uc815\ub4e4\uc758 \ub2e4\uc778\uc790 \uc131\uaca9\uc744 \uac15\uc870\ud569\ub2c8\ub2e4. \uc774\ub294 \uc804\ud1b5\uc801\uc73c\ub85c \ud45c\uc801\ud654\ub41c \uc911\uc7ac\uc758 \uc81c\ud55c\uc801\uc778 \uc131\uacf5\uc744 \uc124\uba85\ud560 \uc218 \uc788\uc73c\uba70, \uc57d\ubb3c \uce58\ub8cc, \ub300\uc0ac \uce58\ub8cc, \ubbf8\uc0dd\ubb3c\uad70 \ud45c\uc801 \uce58\ub8cc\ub97c \uacb0\ud569\ud55c \ub354 \uc2dc\uc2a4\ud15c\uc801\uc778 \uc811\uadfc\ubc95\uc73c\ub85c\uc758 \ud328\ub7ec\ub2e4\uc784 \uc804\ud658\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

“`<\/p>\n

\n

Sources du m\u00e9dia<\/h2>\n

Document de r\u00e9f\u00e9rence<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41380-026-03663-8<\/a><\/p>\n

Titre\u00a0:<\/strong> Efficacy of pharmacological and microbiota-based therapies in preclinical models of autism spectrum disorder: a systematic review<\/p>\n

Revue : <\/strong> Molecular Psychiatry<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Arnas Kunevi\u010dius; Kinga Gawli\u0144ska; Aurelijus Burokas; Dawid Gawli\u0144ski<\/p>\n","protected":false},"excerpt":{"rendered":"

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