MDMA, a substance known for its euphoric and empathogenic effects, is generating increasing interest in the medical field for its therapeutic potential. When used in controlled doses, it could help individuals suffering from psychological disorders related to deep trauma. Research conducted on healthy volunteers shows that MDMA, in doses ranging from 75 to 125 milligrams, promotes an increase in positive mood, empathy, trust, and prosocial feelings. These effects are linked to an increased release of certain chemical messengers in the brain, such as serotonin, dopamine, and norepinephrine.<\/p>\n
During intoxication, MDMA temporarily alters the ability to encode new memories, which could facilitate the processing of trauma by reducing the vividness of negative memories. However, it does not make individuals more suggestible or vulnerable to false information. Executive functions, such as impulse control, remain largely preserved, although motor coordination and cognitive flexibility may be slightly diminished.<\/p>\n
These effects vary depending on metabolism, immune response, drug interactions, and context of use. After ingestion, a temporary drop in mood and fatigue may occur, reflecting a short-term decrease in chemical messengers in the brain. In a therapeutic setting, these properties could strengthen the relationship between the patient and the therapist, thereby fostering the openness and trust needed to address painful memories.<\/p>\n
However, the use of MDMA in therapy requires rigorous monitoring. Patients may be more vulnerable to emotional abuse or dependency due to their altered state of consciousness. Additionally, side effects such as fatigue or mild depressive mood after use must be anticipated and managed carefully.<\/p>\n
Studies also emphasize the importance of adjusting doses based on individual characteristics, such as sex or genetics, to maximize benefits while minimizing risks. Finally, the integration of MDMA into therapeutic protocols must be governed by strict rules to ensure the safety and effectiveness of the treatment.<\/p>\n
DOI:<\/strong> https:\/\/doi.org\/10.1038\/s41380-026-03602-7<\/a><\/p>\n Title:<\/strong> Subjective and neurocognitive profiling of clinical doses of 3,4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use<\/p>\n Journal:<\/strong> Molecular Psychiatry<\/p>\n Publisher:<\/strong> Springer Science and Business Media LLC<\/p>\n Authors:<\/strong> Johannes G. Ramaekers; Kim P. C. Kuypers; Franz X. Vollenweider<\/p>\n","protected":false},"excerpt":{"rendered":" Can MDMA Transform the Therapy of Psychological Trauma? MDMA, a substance known for its euphoric and empathogenic effects, is generating increasing interest in the medical field for its therapeutic potential. When used in controlled doses, it could help individuals suffering from psychological disorders related to deep trauma. Research conducted on healthy volunteers shows that MDMA,… Continue reading Can MDMA Transform the Therapy of Psychological Trauma?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,7],"tags":[],"class_list":["post-42","post","type-post","status-publish","format-standard","hentry","category-health","category-human-humanitarian","entry"],"_links":{"self":[{"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/posts\/42","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/comments?post=42"}],"version-history":[{"count":1,"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/posts\/42\/revisions"}],"predecessor-version":[{"id":43,"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/posts\/42\/revisions\/43"}],"wp:attachment":[{"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/media?parent=42"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/categories?post=42"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/psychiatryfoundation.com\/en\/wp-json\/wp\/v2\/tags?post=42"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}